Niacinamide vs Vitamin C: Which Antioxidant Should You Use?

When it comes to achieving healthy, glowing skin, few ingredients get as much attention as niacinamide and vitamin C. Both are powerful antioxidants with proven benefits, but they work differently — and knowing how (and when) to use them can transform your skincare routine.

Here’s everything you need to know about niacinamide vs vitamin C, including how they compare, who they’re best for, and whether you can use them together.

What is Niacinamide?

Niacinamide, also known as vitamin B3, is a water-soluble vitamin that supports the skin’s barrier function and improves its overall health.

Key Benefits of Niacinamide:

• Strengthens the skin barrier
• Reduces redness and inflammation
• Minimises enlarged pores
• Balances oil production
• Smooths uneven skin tone

It’s suitable for all skin types, including sensitive and acne-prone skin, because it’s generally well-tolerated and non-irritating.

Check our Hero Serum for more information.

What is Vitamin C?

Vitamin C (ascorbic acid) is a powerful antioxidant that helps protect the skin from free radical damage caused by pollution, UV exposure, and lifestyle factors.

Key Benefits of Vitamin C:

• Brightens dull skin and improves radiance
• Reduces the appearance of pigmentation and dark spots
• Boosts collagen production for firmer skin
• Provides antioxidant protection against environmental stress

However, vitamin C is more unstable and active, meaning it can cause irritation in sensitive skin if used in high concentrations.

Niacinamide vs Vitamin C: Key Differences

Should You Use Niacinamide or Vitamin C?

The answer depends on your skin type and goals:

• Choose Niacinamide if: you have sensitive, oily, or acne-prone skin and want to strengthen your skin barrier.
• Choose Vitamin C if: you’re targeting hyperpigmentation, uneven tone, or fine lines.
• Use Both if: you want comprehensive antioxidant protection and the benefits of both ingredients.

Can You Use Niacinamide and Vitamin C Together?

For years, it was believed that niacinamide and vitamin C shouldn’t be combined because they could cancel each other out. However, modern formulations have proven this is a myth.

You can safely use both in your routine — either layered (vitamin C in the morning, niacinamide in the evening) or together in well-formulated serums.

How Each Ingredient Targets Pigmentation

Both niacinamide and vitamin C can improve uneven skin tone, but they do it differently. Vitamin C reduces the activity of tyrosinase, an enzyme responsible for melanin production, which helps fade dark spots and sun damage. Niacinamide, on the other hand, prevents the transfer of pigment within the skin, making it effective for post-acne marks and blotchiness. Combining the two can provide a dual-action brightening effect.

The Science Behind Their Antioxidant Power

Antioxidants are essential for fighting oxidative stress, which accelerates signs of ageing. Vitamin C directly neutralises free radicals caused by pollution and UV rays, while niacinamide strengthens the skin barrier, making it more resilient against environmental damage. Think of vitamin C as your frontline defender, and niacinamide as your reinforcement shield. Pair them with other antioxidant skincare products for maximum protection.

How to Choose the Right Formula

Not all serums are created equal. For vitamin C, look for stable forms like ascorbic acid (10–20%), or derivatives such as sodium ascorbyl phosphate if your skin is sensitive. For niacinamide, concentrations of 2–10% are common — higher levels may help with acne and oil regulation. Always store vitamin C products away from heat and light to prevent oxidation.

Pairing With Other Ingredients

If you’re building a full skincare routine, consider how niacinamide and vitamin C interact with other actives. Niacinamide works well with retinol and ceramides to strengthen the skin barrier. Vitamin C pairs beautifully with vitamin E and ferulic acid, which enhance stability and boost antioxidant protection.

When to Apply Each Ingredient

• Morning: Vitamin C works best in the AM to defend against free radical damage throughout the day. Always follow with SPF.
• Evening: Niacinamide can be applied at night to calm and repair the skin barrier after exposure to daily stressors.
• Combination: If your product contains both, follow the brand’s usage instructions for maximum effectiveness.

FAQs

1. Which is stronger, niacinamide or vitamin C?
Vitamin C is more potent for brightening, while niacinamide is gentler but excellent for barrier support.

2. Can I layer vitamin C and niacinamide in the same routine?
Yes — most modern serums are stabilised to work together. Apply vitamin C first, then niacinamide.

3. Which is better for acne-prone skin?
Niacinamide is usually the better choice, as it reduces oil production and inflammation.

4. Can sensitive skin use vitamin C?
Yes, but start with a lower concentration (around 10%) and patch test first.

Final Thoughts

Both niacinamide and vitamin C are skincare powerhouses — but they shine in different ways. Niacinamide is the calm, steady barrier-builder, while vitamin C is the brightening, protective antioxidant. Together, they make a complementary duo that can address multiple skin concerns at once.

👉 If you’re looking for healthier, more resilient skin, don’t think of it as niacinamide vs vitamin C — think of it as niacinamide + vitamin C.